TARGETING CDCP1 BOOST CD8+ T CELLS-MEDIATED CYTOTOXICITY IN CERVICAL CANCER VIA THE JAK/STAT SIGNALING PATHWAY

Targeting CDCP1 boost CD8+ T cells-mediated cytotoxicity in cervical cancer via the JAK/STAT signaling pathway

Background Cervical cancer remains a global health challenge.The identification of new immunotherapeutic targets may provide a promising platform for advancing cervical cancer treatment.Objective This study aims to investigate the role of CUB domain-containing protein 1 (CDCP1) in cervical cancer progression and evaluate its potential as a therapeu

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Artemisinin-Based Combination Therapy Depressed Mitosis and Induced Chromosome Aberration in Onion Root Cells

Artemisinin-based combination therapy is used to treat uncomplicated malaria disease in most endemic countries.Although most antimalarial drugs are effective in killing the parasite, there is a concern of induced toxicity to the cell.Here, the cytogenotoxicity of dihydroartemisinin-piperaquine phosphate (DHAP), a coformulation for artemisinin-based

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Beware of Steroid-Induced Avascular Necrosis of the Femoral Head in the Treatment of COVID-19—Experience and Lessons from the SARS Epidemic

Shenqi Zhang,1– 3 Chengbin Wang,3 Lei Shi,1 Qingyun Xue1,2 1Department of Orthopedics, Beijing Hospital, National Center of Gerontology, Beijing, People’s Republic of China; 2Peking Switch Panel Union Medical College, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China; 3Department of Joint and Sports Medicine

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GEOLOGICAL EVOLUTION AND OIL AND GAS CONTENT OF LOCAL UPLIFTS OF THE BAKU ARCHIPELAGO OF THE SOUTH CASPIAN BASIN

The research relevance is backed by the need to expand the resource potential of the western flank of the South Caspian basin and increase production in some oilfields of the B-6 Baku Archipelago.The aim of the research is to determine structural evolution features, paleogeographic, pressure and temperature environment and the deposition rate in or

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